| Rnd | Match Date | Home Team | Result | Away Team |
|---|
| 1 | 2021-11-14 | Murrumbeena | no play | South Caulfield |
| 2 | 2021-11-21 | Murrumbeena |  | Oakleigh |
| 3/136 O Scott-Waters 50N L Anstee 27 | | 7/114 A Dehne 2/10 S Briggs 2/17 |
| 3 | 2021-11-28 | Maccabi Ajax Warriors | | Murrumbeena |
| 35 S Adapa 2/2 S Darvell 2/3 R Parton 4/2 | | 2/120 O Scott-Waters 50N S Briggs 50N |
| 4 | 2021-12-05 | Emmanuel Sth Oakleigh | def | Murrumbeena |
| 5/107 | | 8/67 |
| 5 | 2021-12-12 | Murrumbeena | | Clayton District |
| 9/111 | | 8/108 J Welcome 3/11 O Scott-Waters 2/2 |
| 6 | 2021-12-19 | Oakleigh | drew | Murrumbeena |
| 5/93 | | 9/83 |
| 7 | 2022-01-23 | Brighton District | | Murrumbeena |
| 9/60 R Parton 3/3 | | 5/144 R Parton 31 R Crough 39 O Scott-Waters 30* S Briggs 25 |
| 8 | 2022-01-30 | Oakleigh | def | Murrumbeena |
| 3/101 | | 8/78 |
| 9 | 2022-02-06 | Murrumbeena | | Emmanuel Sth Oakleigh |
| 6/115 R Parton 39 O Scott-Waters 35 | | 4/109 L Anstee 2/10 |
| 10 | 2022-02-13 | Clayton District | | Murrumbeena |
| 58 R Parton 3/7 S Adapa 3/9 C Cegarra Fenton 2/8 | | 3/120 R Parton 26 L Anstee 38 S Darvell 29* |
| 11 | 2022-02-20 | Murrumbeena | lost to | Clayton District |
| 78 | | 6/92 R Parton 2/6 J Ansell 2/9 |
| 12 | 2022-02-27 | Murrumbeena | | Brighton District |
| 4/122 R Parton 50N O Scott-Waters 26 | | 6/102 |
| 13 | 2022-03-06 | Ashwood | no play | Murrumbeena |
| SF | 2022-03-13 | South Caulfield | def | Murrumbeena |
| 5/79 | | 4/78 R Crough 28N |
